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Conformation of Protein
Protein conformation plays a crucial role in the understanding of protein function, stability, and interactions with other molecules. Scientists have employed various methods to unravel the intricate three-dimensional structures of proteins. X-ray crystallography utilizes X-ray diffraction to precisely determine the atom locations in protein crystals, while NMR spectroscopy exploits the magnetic properties of atoms in…
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Cryo Electron Microscopy (Cryo-EM)
Cryo-EM is a cutting-edge imaging technique used for studying the structure of biological macromolecules such as proteins and nucleic acids. By using a cryogenic electron microscope, researchers can capture high-resolution images of frozen, hydrated samples, preserving their native state and avoiding radiation damage. The sample preparation is a crucial step that involves rapid freezing of…
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