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Conformation of Protein
Protein conformation plays a crucial role in the understanding of protein function, stability, and interactions with other molecules. Scientists have employed various methods to unravel the intricate three-dimensional structures of proteins. X-ray crystallography utilizes X-ray diffraction to precisely determine the atom locations in protein crystals, while NMR spectroscopy exploits the magnetic properties of atoms in…
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Ramachandran Plot
Explore the Ramachandran plot, a vital tool in structural biology for analyzing protein conformation and folding. Understand the significance of phi and psi angles, interpret the plot, and its applications in protein structure prediction and refinement. Discover how the plot aids in unraveling protein folding pathways and assessing stability. Gain insights into protein engineering and…
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Protein Folding
Dive into the fascinating world of protein folding, where linear sequences of amino acids transform into intricate three-dimensional structures. Discover the driving forces behind protein folding, such as the hydrophobic effect and hydrogen bonding. Explore the stages of protein folding, from primary to tertiary structure, and unravel its applications in understanding protein function, designing drugs,…
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Secondary Structures of Proteins
Protein secondary structure, including alpha helix and beta sheet, plays a vital role in protein function and stability. Explore their characteristics, discover their importance in drug design and protein engineering, and learn about their applications in biotechnology.
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Structure of Protein
Proteins are essential macromolecules that play a crucial role in many biological processes. They are made up of amino acids, which are linked together through peptide bonds to form a linear chain. The sequence of amino acids in a protein determines its three-dimensional structure and, consequently, its function. In this study note, we will explore…
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Nuclear Magnetic Resonance (NMR)
The Nuclear Magnetic Resonance (NMR) technique is a powerful tool used in biophysics to study the structure, dynamics, and interactions of biomolecules in solution. NMR spectroscopy is based on the principle that certain atoms’ nuclei can absorb and emit electromagnetic radiation in the radiofrequency range when placed in a strong magnetic field. This technique can…
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Circular Dichroism (CD) Technique
Circular dichroism (CD) is a powerful spectroscopic technique used to study the structure and properties of chiral molecules, such as proteins, nucleic acids, and carbohydrates. It is based on the differential absorption of left and right circularly polarized light by chiral molecules, which can provide information on their secondary, tertiary, and quaternary structures. In this…
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